Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals

Abstract

Obesity renders macrophages more susceptible to [Ca²⁺]_ex-induced IL-1β release and pyroptosis. Increased susceptibility was independent of the response to LPS and circulating CRP arguing against mere pro-inflammatory pre-activation of monocytes. Instead, we propose that CaSR mediated signalling is relevant for the deleterious innate immune activation in obesity.