Anxiolytic, antidepressant and antioxidant activity of the methanol extract of Canarium resiniferum leaves

Abstract

MECR, at all doses, showed dose-dependent anxiolytic activity. At 400 mg/kg, it significantly increased the time spent and number of entries in the open arms (EPM test), the number of head-dips (HBT), and the time spent into the light compartment (LDB) test compared to the control. In the TST and FST, MECR dose-dependently reduced the duration of immobility compared to untreated animals. This was significant for all doses except for 100 mg/kg in the FST model. MECR showed high TPC and TFC (90.94 ± 0.75 mg GAE/g and 51.54 ± 0.78 mg QE/g of dried extract, respectively) and displayed potent activity in the DPPH radical scavenging (IC₅₀ = 177.82 μg/mL) and FRAP assays. These findings indicate that <i>C. resiniferum</i> has the potential to alleviate anxiety and depression disorders, which merits further exploration.