Anticancer Research · 2022 · 12 citations · 49 references
Life SciencesImmunologyOncologyCancer GeneticsCancer ImmunologyImmunogeneticsBreast Cancer Risk AssessmentCancer RiskCytokine BiologyCytokine Gene PolymorphismGenetic Risk AssessmentGenetic Risk PredictionAge-specific Risk AssessmentAllelic Frequency VariationCancer Risk AssessmentCancer Risk AssociationDisease Susceptibility AssociationInterleukin-8 Gene VariantsStratificationTumor Cell Proliferation
BACKGROUND/AIM: Triple negative breast cancer (TNBC) is one of the most challenging breast cancer types. Interleukin-8 (IL-8) is a pro-tumorigenic cytokine, promoting tumor proliferation and migration. This study aimed to examine the contribution of IL-8 rs4073 genotypes to breast cancer risk and provide a summary of related literature. MATERIALS AND METHODS: IL-8 genotypic profiles were determined among 1,232 breast cancer cases and 1,232 controls via polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The IL-8 rs4073 AT and AA genotypes had significantly lower prevalence in the case group compared to control group. Allelic frequency analysis showed that individuals carrying the A allele have relatively decreased risk for breast cancer. The stratification analysis showed that IL-8 rs4073 genotypes were protective markers for those with younger (≤55) age. CONCLUSION: IL-8 rs4073 A allele is a novel predictor for breast cancer, especially TNBC.
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Rebecca L. Siegel, Kimberly D. Miller, Hannah E. Fuchs et al. · CA A Cancer Journal for Clinicians · 2022 · 18.2K citations · Full text
Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis
Alisa E. Koch, Peter J. Polverini, Steven L. Kunkel et al. · Science · 1992 · 2.1K citations