Concepedia

Increased Expression and Amplification of <i>bla</i> <sub>KPC-2</sub> Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain

Xinhui Li, Jisheng Zhang, Chengru Yang, Jie Li, Jianmin Wang, Wan Huang, Lingyi Zeng, Xushan Liang, Wenzhang Long, Xiaoli Zhang

Microbiology Spectrum · 2022 · 19 citations · 22 references

DOIFull text

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Concepts

Abstract

Klebsiella pneumoniae carbapenemase (KPC) production is the most common mechanism of K. pneumoniae resistance to carbapenems in China. Currently, CAZ/AVI is considered a potential alternative therapeutic option for infections caused by these isolates.

References

22

Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China

Rong Zhang, Lizhang Liu, Hongwei Zhou et al. · EBioMedicine · 2017 · 566 citations · Full text

, , +14

<i>Klebsiella pneumoniae</i>Outer Membrane Porins OmpK35 and OmpK36 Play Roles in both Antimicrobial Resistance and Virulence

Yu-Kuo Tsai, Chang‐Phone Fung, Jung‐Chung Lin et al. · Antimicrobial Agents and Chemotherapy · 2011 · 337 citations · Full text

, , +17

Movement of IS <i>26</i> -Associated Antibiotic Resistance Genes Occurs via a Translocatable Unit That Includes a Single IS <i>26</i> and Preferentially Inserts Adjacent to Another IS <i>26</i>

Christopher J. Harmer, Robert A. Moran, Ruth M. Hall · mBio · 2014 · 329 citations · Full text

, , +17

Insertion Sequence IS <i>26</i> Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition

Susu He, Alison B. Hickman, Alessandro M. Varani et al. · mBio · 2015 · 316 citations · Full text

, , +17

First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate

Romney M. Humphries, Shangxin Yang, Peera Hemarajata et al. · Antimicrobial Agents and Chemotherapy · 2015 · 257 citations · Full text

, , +17