Physics in Medicine and Biology · 2022 · 23 citations · 20 references
MedicineRadiation OncologyRadiation DosimetryRadiation MeasurementTreatment PlanningExternal Beam RadiotherapyParticle TherapyProton DosimetryProton TherapyRadiation TherapyTreatment Planning Dose CalculationBeam Delivery SystemsBeam ScanningParticle Beam DosimetryPencil Beam DosimetryPencil Beam ScanningProton Dose CalculationProton Therapy DosimetrySpot Scanning
Abstract Objective. To investigate synchrotron-based proton pencil beam scanning (PBS) beam delivery time (BDT) using novel continuous scanning mode. Approach. A BDT calculation model was developed for the Hitachi particle therapy system. The model was validated against the measured BDT of 36 representative clinical proton PBS plans with discrete spot scanning (DSS) in the current Hitachi proton therapy system. BDTs were calculated with the next generation using Mayo Clinic Florida system operating parameters for conventional DSS, and novel dose driven continuous scanning (DDCS). BDTs of DDCS with and without Break Spots were investigated. Main results. For DDCS without Break Spots, the use of Stop Ratio to control the transit dose largely reduced the beam intensity and consequently, severely prolonged the BDT. DDCS with Break Spots was able to maintain a sufficiently high beam intensity while controlling transit dose. In DDCS with Break Spots, tradeoffs were made between beam intensity and number of Break Spots. Therefore, BDT decreased with increased beam intensity but reached a plateau for beam intensity larger than 10 MU s −1 . Averaging over all clinical plans, BDT was reduced by 10% for DDCS with Break Spots compared to DSS. Significance. DDCS with Break Spots reduced BDT. DDCS has the potential to further reduce BDT under the ideal scenario which requests both stable beam intensity extraction and accurately modelling the transit dose. Further investigation is warranted.
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Intensity modulation methods for proton radiotherapy
Antony Lomax · Physics in Medicine and Biology · 1999 · 536 citations
Michael T. Gillin, Narayan Sahoo, Martin Bues et al. · Medical Physics · 2009 · 274 citations · Full text