Organic Letters · 2022 · 18 citations · 37 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryOrganic SynthesisSafer Chemical SynthesisSafer SolventsC - H Bond FunctionalizationFunctional Group ToleranceKetone FunctionalizationMetal CatalystsMild Reaction ConditionsScale-up SynthesisSilylation ReactionsTransition Metal Catalysts
An efficient method for the synthesis of β,β-di(hetero)aryl-α,α-difluorinated ketones using readily available organophosphonium salts and difluoroenol silyl ethers has been developed. This mild reaction features a good functional group tolerance, a scaled-up synthesis, and synthetic simplicity. By taking advantage of DMSO as a less-toxic promoter and solvent for the difluoroalkylation and C-P bond functionalization, the use of transition-metal catalysts and sensitive additives could be avoided.
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DMSO-catalysed late-stage chlorination of (hetero)arenes
Song Song, Xinyao Li, Jialiang Wei et al. · Nature Catalysis · 2019 · 221 citations