<i>Lactobacillus johnsonii</i> 6084 alleviated sepsis‐induced organ injury by modulating gut microbiota

Abstract

Sepsis is a public cause of death in intensive care unit patients. Probiotics were widely used to increase the survival rate of sepsis by a series of clinical research. The purpose of this research was to investigate the therapeutic effects of <i>Lactobacillus johnsonii</i> 6084 in septic mice. Sepsis mouse model was induced by LPS treatment. The influence of <i>L. johnsonii</i> 6084 on the protection of organ injury induced by sepsis was explored. Moreover, the composition of gut microbiota was studied to clarify the mechanism of <i>L. johnsonii</i> 6084 therapeutic effect on sepsis. <i>L. johnsonii</i> 6084 treatment could conspicuously decrease the mortality and organ injury of sepsis. The reduction of gut microbial diversity and richness in septic mice were moderated by the administration of 6084. The abundance of <i>Bacteroidetes</i> and <i>Proteobacteria</i> were change by LPS treatment while restored by <i>L. johnsonii</i> 6084. To conclude, probiotic 6084 may has optimistic result on reducing mortality of sepsis through rebalancing gut microbiota.