Visualizing the mode of action and supramolecular assembly of teixobactin analogues in <i>Bacillus subtilis</i>

Abstract

reveals a correlation between cell death and binding of the antibiotic to cellular targets, followed by lysis of cells. Collectively, these studies provide new insights into the binding of teixobactin to Gram-positive bacteria, its supramolecular mechanism of action, and the lysis of bacteria that follows.