Concepedia

Switchable photocatalysis for the chemodivergent benzylation of 4-cyanopyridines

Eleni Georgiou, Davide Spinnato, Kang Chen, Paolo Melchiorre, Kilian Muñiz

Chemical Science · 2022 · 32 citations · 30 references

DOIFull text

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Concepts

Abstract

radical coupling and a Minisci-type addition, enabled selective access to regioisomeric C4 or C2 benzylated pyridines, respectively. Mechanistic investigations shed light on the origin of the chemoselectivity switch.

References

30

Photoredox Catalysis in Organic Chemistry

Megan H. Shaw, Jack Twilton, David W. C. MacMillan · The Journal of Organic Chemistry · 2016 · 3.1K citations · Full text

, , +14

Discovery of an α-Amino C–H Arylation Reaction Using the Strategy of Accelerated Serendipity

Andrew McNally, Christopher K. Prier, David W. C. MacMillan · Science · 2011 · 1K citations

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Photoredox Activation for the Direct β-Arylation of Ketones and Aldehydes

Michael T. Pirnot, Danica A. Rankic, David B. C. Martin et al. · Science · 2013 · 562 citations

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Nucleophilic character of alkyl radicals—VI

Francesco Minisci, R. BERNARDI, F. Bertini et al. · Tetrahedron · 1971 · 473 citations

, , +3

Direct α‐Arylation of Ethers through the Combination of Photoredox‐Mediated CH Functionalization and the Minisci Reaction

Jian Jin, David W. C. MacMillan · Angewandte Chemie International Edition · 2014 · 453 citations · Full text

, , +16