Asymmetric synthesis of polycyclic spiroindolines <i>via</i> the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines

Abstract

An asymmetric cascade reaction catalyzed by a chiral N , N ′-dioxide–Dy( iii ) complex was realized to construct the valuable [6,5,5,6] tetracyclic spiroindolines with good yields and enantioselectivities by a concise and one-step protocol.