Highly enantioselective Ni-catalyzed asymmetric hydrogenation of β,β-disubstituted acrylic acids

Abstract

A highly enantioselective Ni-catalyzed hydrogenation of β,β-disubstituted acrylic acids was first realized using Ph-BPE, providing straightforward access to chiral carboxylic acids in high yields with excellent enantioselectivities, up to 99% ee.