Chemical Communications · 2022 · 11 citations · 22 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryEnzymologyEnzyme InhibitionLead Compound DesignLead DiscoveryN-linked GlycosylationO-linked GlycosylationProtein GlycoengineeringAlzheimer Disease Tau PathologyGalnac TransferasesO-linked N-acetylglucosamine ModificationStructure-based Lead DiscoveryStructure-guided Lead DiscoveryTau GlycationTau HyperphosphorylationTau Post-translational Modifications
We report the synthesis and testing of a novel type (new lead structure) of powerful and highly selective human O-N -acetyl-β- d -glucosaminidase (enzyme associated with Alzheimer's disease) inhibitors that are not based on transition state mimetics.
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The carbohydrate-active enzymes database (CAZy) in 2013
Vincent Lombard, Hemalatha Golaconda Ramulu, Élodie Drula et al. · Nucleic Acids Research · 2013 · 6.5K citations · Full text
O-GlcNAcase Uses Substrate-assisted Catalysis
Matthew S. Macauley, Garrett E. Whitworth, Aleksandra W. Debowski et al. · Journal of Biological Chemistry · 2005 · 367 citations · Full text