Copper-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes to construct SCF₃-containing dioxodibenzothiazepines

Abstract

A mild and efficient Cu-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes with readily available and stable AgSCF₃ as the trifluoromethylthiolating reagent has been disclosed. This transformation provides an opportunity to construct a series of potential medicinally valuable trifluoromethylthio-substituted dioxodibenzothiazepines with wide functional group compatibility. This protocol opens up a new avenue for the construction of useful trifluoromethylthiolated seven-membered N-heterocycles.