Exploratory study of seed spots analysis to characterize dose and linear‐energy‐transfer effect in adverse event initialization of pencil‐beam‐scanning proton therapy

Abstract

Our exploratory study showed that both dose and LET were observed to be important in AE initializations. The derived xBD volume constraint could predict mandible osteoradionecrosis reasonably well in the very limited H&N cancer patient data treated with PBS included in this study.