CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson's disease - Concepedia

Concepedia

Publication | Open Access

CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson's disease

DOI Full Paper Access

17

Citations

23

References

2022

Year

Lin Lü, Hengxu Mao, Miaomiao Zhou, Yuwan Lin, Wei Dai, Jiewen Qiu, Yousheng Xiao, Mingshu Mo, Xiaoqin Zhu, Zhuohua Wu,

Chinese Medical Journal

Abstract

This study indicated that CHCHD2 could interact with Mic10 and maintain the stability of the MICOS complex, which contributes to protecting mitochondrial function in PD.

References

	Year	Citations
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study Manabu Funayama, Kenji Ohe, Taku Amo, The Lancet Neurology Neurodegenerative DiseasesChchd2 MutationsMendelian DisorderGenetic DisorderGenetics	2015	346
ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function Manjula Darshi, Vincent Louie Mendiola, Mason Mackey, Journal of Biological Chemistry Mitochondrial Inner MembraneMitophagyBiochemistryMitochondrial FunctionOuter Membrane	2010	323
Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex Martijn A. Huynen, Mareike Mühlmeister, Katherina Gotthardt, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research	2015	201
<i> <scp>CHCHD</scp> 10 </i> mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis Emmanuelle C. Genin, Morgane Plutino, Sylvie Bannwarth, EMBO Molecular Medicine	2015	199
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2 Siddhesh Aras, Oleg Pak, Natascha Sommer, Nucleic Acids Research	2013	178
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization Hao Li, Yunfeng Ruan, Kuan Zhang, Cell Death and Differentiation Mitochondrial FunctionMitochondrial DynamicMic60/mitofilin Determines MicosNatural SciencesMitochondrial Dynamics	2015	174
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism Siddhesh Aras, Minbo Bai, Icksoo Lee, Mitochondrion MitophagyMitochondrial BiogenesisMitochondrial FunctionGeneticsMolecular Biology	2014	173
QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology Virgínia Guarani, Elizabeth M. McNeill, João A. Paulo, eLife Molecular BiologyMolecular GeneticsNovel Mitochondrial ProteinCellular PhysiologyProteomics	2015	172
Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c Hongrui Meng, Chikara Yamashita, Kahori Shiba‐Fukushima, Nature Communications	2017	172
Mic10 Oligomerizes to Bend Mitochondrial Inner Membranes at Cristae Junctions Mariam Barbot, Daniel C. Jans, Christian Schulz, Cell Metabolism BiochemistryProtein FoldingMembrane TransportNatural SciencesMolecular Biology	2015	164

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