Cytokine level in patients with mood disorder, alcohol use disorder and their comorbidity

Abstract

OBJECTIVES: Because alcohol use disorder (AUD) is often accompanied by mood disorder (MD) and both alcoholism and depression result in activation of the immune system, this study compares serum cytokine levels in the presence of co-morbidity with those in either AUD or MD alone. METHODS: = 42). The levels were compared cross-sectionally among themselves and with those in 50 healthy volunteers. RESULTS: = 0.015) in contrast with MD + AUD group. CONCLUSIONS: Because the interactions of alcohol with peripheral and cerebral immune systems are multifaceted, the pertinent connection to the mechanism how alcohol consumption contributes to the development of mood disorders cannot be properly explored.