Journal of Materials Chemistry B · 2022 · 14 citations · 29 references
Natural SciencesCell BiologyOncologyBiomedical OpticsBiophysical ChemistryMolecular ImagingCellular ImagingFluorescence ImagingFluorescence MicroscopyFluorescence SpectroscopyOptical SpectroscopyPhotophysics Of Fluorescent ProbesCellular Fluorescence ImagingEndoplasmic Reticulum TargetingFluorescence Contrast AgentsFluorescence ProbesFluorescent DyesFluorescent ProbesMolecular Fluorescence ImagingStokes Shift
= 0.13). In addition, cell colocalization experiments showed that probe 1 (3 μM) was located in the endoplasmic reticulum in cancer cells, while it could target lysosomes in normal cells. What's more, further cell imaging experiments demonstrated that the average fluorescence intensity of probe 1 (0.3 μM) in cancer cells increased with the addition of β-CD, but it did not occur in normal cells. The study provides a convenient way to distinguish cancer cells from normal ones, which has potential for application in the early detection of cancer.
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