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Publication | Open Access

The integrin ligand SVEP1 regulates GPCR‐mediated vasoconstriction via integrins α9β1 and α4β1

DOIFull Paper Access

12

Citations

48

References

2022

Year

G E Morris, Matthew Denniff, Elisavet Karamanavi, Sarah A. Andrews, Renata B. Kostogrys, Vassiliki Bountziouka, Maryam Ghaderi‐Najafabadi, Noor Shamkhi, George McConnell, Michael Kaiser,
British Journal of Pharmacology

Abstract

Our studies reveal a novel role for SVEP1 and the integrins α4β1 and α9β1 in reducing VSMC contractility. This could provide an explanation for the genetic associations with blood pressure risk at the SVEP1 and ITGA9 loci.

References

YearCitations

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