Comparative clinical study for the efficacy and safety of two different hyaluronic acid‐based fillers with <scp>Tri‐Hyal</scp> versus Vycross technology: A long‐term prospective randomized clinical trial

Abstract

The observations confirmed the non-inferiority of ART FILLER® Volume versus the reference product on the different injected areas. For both fillers, the beneficial effects on volumes restoration were maintained 18 months post-injection; however, these effects were diminished among the time. Furthermore, injections of Art Filler® Volume were well tolerated by the subjects and showed less acute side effects compared with the reference product that may be explained by a lower induction of inflammation.