Cell Reports Medicine · 2022 · 71 citations · 83 references
Life SciencesImmunologyInfectious DiseasesInflammationMulti-omics IntegrationProteomicsInflammatory BiomarkersProteomic ProfilingProteomics Data IntegrationSingle-cell AnalysisSingle-cell Multi-omics IntegrationSingle-cell ProteomicsImmune Biomarker DiscoveryImmune Biomarker ProfilingImmune Signature ProfilingProteomic Data AnalysisSingle-cell BiomarkersSingle-cell Immune AnalysisSingle-cell Multiomics IntegrationSingle-cell Proteomics Integration
= 0.773, p = 7.7e-6). Examination of informative model features reveals biological signatures of COVID-19 severity, including the dysregulation of JAK/STAT, MAPK/mTOR, and nuclear factor κB (NF-κB) immune signaling networks in addition to recapitulating known hallmarks of COVID-19. These results provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for prevention and/or treatment of COVID-19 progression.
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