American Journal of Physiology-Heart and Circulatory Physiology · 2022 · 45 citations · 61 references
EducationCardiologyPhysiologyAgingCardiovascular GeneticsGerontologyAge-related Physiological ChangesAging PhysiologyCardiovascular AgingCardiovascular DiseaseEndothelial DysfunctionGenetics Of AgingAge-associated Vascular ChangesAge-related Cardiovascular ChangesAge-related Vascular ChangesAging-related Vascular ChangesBlood PressureEndothelial SenescenceSex Differences In AgingVascular Endothelial Dysfunction
Indices of vascular aging were different in male and female mice. Sex differences in pulse wave velocity, blood pressure, and large artery stiffness were abrogated in middle-aged mice, but the female advantage in resistance artery vasodilator function was maintained. GPER deletion abrogated these sex differences and significantly reduced endothelial function in adult female mice. Additional studies are needed to characterize sex differences in vascular aging to personalize early detection and treatment for vascular diseases.
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