Phytochemical Investigation of Cordia africana Lam. Stem Bark: Molecular Simulation Approach

Abstract

The antibacterial activity of the stem bark of <i>Cordia africana</i> Lam. was evidenced against MRSA and <i>H. pylori</i>. Computational modeling of the studied enzyme-ligands systems reveals that RA and MR can potentially inhibit both MRSA peptidoglycan transpeptidases and <i>H. pylori</i> urease, thereby creating a pathway via the use of a double target approach in antibacterial treatment.