Phospholipase A2 inhibitor varespladib prevents wasp sting-induced nephrotoxicity in rats

A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth et al. · Nature Communications · 2020 · 165 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +15

Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

Idris Boudhabhay, Victoria Poillerat, Anne Grünenwald et al. · Kidney International · 2020 · 93 citations · Full text

Medicine, Immunology, Nephrology +16

Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation

Yiding Wang, Jing Zhang, Denghong Zhang et al. · Molecules · 2018 · 88 citations · Full text

Pharmacy, Pharmacology, Toxicology +16

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

Antoniel Augusto Severo Gomes, Wendy Bryan-Quirós, Julián Fernández et al. · Scientific Reports · 2019 · 75 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2

Wendy Bryan-Quirós, Julián Fernández, José Marı́a Gutiérrez et al. · Toxicon · 2018 · 67 citations · Full text

Life Sciences, Biochemistry, Pharmacology +7