Detection of changes in synaptic density in amyotrophic lateral sclerosis patients using <scp>¹⁸F‐SynVesT</scp>‐1 positron emission tomography

Abstract

This approach may provide a direct measure of synaptic density, and it therefore might represent a potentially useful biomarker for ALS diagnosis, as well as for estimating the cognitive decline and site of onset in ALS. ¹⁸ F-SynVesT-1-PET is presently not justified as a routine investigation to detect evidence of brain dysfunction leading to progression in ALS.