Concepedia

Discovery of pyrazolo[3,4-<i>d</i>]pyrimidine and pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[1,5-<i>c</i>]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations

Ibrahim F. Nassar, Mohammed Taha Abdel Aal, Wael A. El‐Sayed, Mahmoud Ahmed Shahin, Elsayed G.E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Mohamed Hagras, Asmaa A. Mandour, Nasser S. M. Ismail

RSC Advances · 2022 · 43 citations · 37 references

DOIFull text

Open access

Concepts

Abstract

ADMET studies and drug-likeness studies using a Boiled Egg chart showed suitable pharmacokinetic properties which helped in structure requirement prediction for the observed antitumor activity.

References

37

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Antoine Daina, Olivier Michielin, Vincent Zoete · Scientific Reports · 2017 · 17.1K citations · Full text

, , +16

A BOILED‐Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

Antoine Daina, Vincent Zoete · ChemMedChem · 2016 · 2.4K citations · Full text

, , +17

Analysis of Cell Cycle by Flow Cytometry

Piotr Pożarowski, Zbigniew Darżynkiewicz · Humana Press eBooks · 2004 · 590 citations

, , +14

A new therapeutic approach in Alzheimer disease: Some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics

Nesrin Gökhan-Kelekçi, Samiye Yabanoğlu, Esra Küpeli̇ et al. · Bioorganic & Medicinal Chemistry · 2007 · 228 citations · Full text

, , +14

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

D.J. Wood, S. Korolchuk, Natalie J. Tatum et al. · Cell chemical biology · 2018 · 156 citations · Full text

, , +12