Concepedia

Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy

Qi Liu, Guangbo Ji, Yushu Chu, Hao Tian, Meng Qian, Qiang Zhao

Chemical Communications · 2022 · 13 citations · 24 references

DOI

Concepts

Abstract

S donor can release nitric oxide and hydrogen sulfide step by step in response to the endogenous enzymes β-galactosidase and carbonic anhydrase, providing potent therapeutic efficacy for heart failure post- myocardial infarction.

References

24

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Chris M. Maragos, Deborah Morley, David A. Wink et al. · Journal of Medicinal Chemistry · 1991 · 721 citations

, , +13

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Mirjam Eberhardt, Mária Dux, Barbara Namer et al. · Nature Communications · 2014 · 372 citations · Full text

, , +17

Positive inotropic and lusitropic effects of HNO/NO <sup>−</sup> in failing hearts: Independence from β-adrenergic signaling

Nazareno Paolocci, Tatsuo Katori, Hunter C. Champion et al. · Proceedings of the National Academy of Sciences · 2003 · 312 citations

, , +16

Reduced Gene Expression of Vascular Endothelial NO Synthase and Cyclooxygenase-1 in Heart Failure

Carolyn J. Smith, Dong Sun, Carl Hoegler et al. · Circulation Research · 1996 · 267 citations

, , +15

Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction

Xinpeng Yao, Yi Liu, Jie Gao et al. · Biomaterials · 2015 · 164 citations

, , +16