Stem Cell Reports · 2022 · 30 citations · 26 references
Life SciencesCell BiologyDevelopmental BiologyCell DifferentiationRegenerative MedicineStem Cell BiologyEmbryonic Stem CellsMacular DegenerationOcular DevelopmentRetinal DevelopmentRetinal Pigment EpitheliumStem Cell DifferentiationCell Source PotencyPluripotent Stem Cell DifferentiationRetinal Pigment Epithelium DifferentiationRetinal Pigment Epithelium Stem CellsRetinal Progenitor Cell DifferentiationRetinal Progenitor CellsRetinal Stem CellsTransient States
retinal progenitor population and showed the ability of the protocol to suppress non-RPE fates. We demonstrated that the method produces a pure RPE pool capable of maturing further after subretinal transplantation in a large-eyed animal model. Our evaluation of hESC-RPE differentiation supports the development of safe and efficient pluripotent stem cell-based therapies for AMD.
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SCENIC: single-cell regulatory network inference and clustering
Sara Aibar, Carmen Bravo González‐Blas, Thomas Moerman et al. · Nature Methods · 2017 · 6.9K citations · Full text
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Molecular Architecture of the Mouse Nervous System
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Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells
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