Exposure to Endocrine-Disrupting Chemicals and Type 2 Diabetes Mellitus in Later Life

Abstract

Abstract Type 2 diabetes mellitus (T2DM), one of the most common chronic metabolic diseases, involves a complex interaction among genetic, epigenetic, and environmental risk factors. The incidence and prevalence of T2DM are rapidly increasing globally. In recent years, increasing body of evidences from both human and animal studies have displayed an association between exposure to early unfavorable life factors such as endocrine-disrupting chemicals (EDCs) and the prevalence of T2DM in later life. The exogenous EDCs can lead to disadvantageous metabolic consequences because they interfere with the synthesis, secretion, transport, binding, action, and metabolism of endogenous hormones. EDCs also have long-term adverse effects on newborns, children, and adolescents by causing increased susceptibility to T2DM in adults. This review summarizes the most recent advances in this field, including diabetes-related EDCs (bisphenol A, phthalates, chlordane compounds, parabens, pesticides, and other diabetes-related EDCs), EDC exposure and gestational diabetes mellitus, prenatal and perinatal EDC exposures and T2DM, adult EDC exposure and T2DM, transgenerational effects of EDCs on T2DM as well as the possible diabetogenic mechanisms.