The hydrogen storage nanomaterial MgH ₂ improves irradiation-induced male fertility impairment by suppressing oxidative stress

Abstract

MgH₂ improved irradiation-induced male fertility impairment by eliminating hydroxyl free radicals. Mice fertility and function were evaluated with or without MgH₂ treatment after 5 Gy irradiation. MgH₂ had the ability of hydroxyl radicals scavenging and MDA suppressing in testicular tissue induced by irradiation. Further, MgH₂ could participate in spermatogenesis and protect sperm development in three stages: the generation of Sertoli cells (Sox-9+), spermatogonia (Stra8+) and round sperm cells (Crem+). Moreover, MgH₂ alleviated the decrease of testosterone secreted by interstitial cells after irradiation. In addition, MgH₂ suppressed apoptosis, pyroptosis and inflammatory response and alleviated cell cycle arrest by mediating IR-induced ROS.