Publication | Open Access
A Route to Lipid ALC‐0315: a Key Component of a COVID‐19 mRNA Vaccine
25
Citations
12
References
2022
Year
EngineeringCovid‐19 Mrna VaccineOverall Yield RelativeImmunologyOrganic ChemistryChemistryCovid-19Chemical EngineeringNovel OrganocatalystsKey ComponentOrganometallic CatalysisVaccine DevelopmentLipid Alc‐0315VirologyConsiderable ExtentCatalysisNatural Product SynthesisMuch Cleaner ReactionsVaccinationAlkene MetathesisVaccine DesignMedicineVaccine ResearchSynthetic Chemistry
This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.
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