Targeting PCSK9 Ameliorates Graft Vascular Disease in Mice by Inhibiting NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells

Abstract

PCSK9 is upregulated in a mouse model of GVD, and <i>Pcsk9</i> knockout reduces vascular occlusion, suggesting that PCSK9 may be a promising target for the treatment of GVD.