Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity

Abstract

In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against <i>Botrytis cinereal</i> (<i>B. cinereal</i>), <i>Botryosphaeria dothidea</i> (<i>B. dothidea</i>), and <i>Phomopsis</i> sp. were determined using the poison plate technique. Biological test results showed that compound <b>6h</b> revealed lower EC₅₀ values (25.9 and 50.8 μg/ml) on <i>Phompsis</i> sp. than those of pyrimethanil (32.1 and 62.8 μg/ml).