TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast–Mediated Epithelial–Mesenchymal Transition in Colorectal Cancer - Concepedia

Concepedia

Publication | Open Access

TGF-β-Induced FLRT3 Attenuation Is Essential for Cancer-Associated Fibroblast–Mediated Epithelial–Mesenchymal Transition in Colorectal Cancer

DOI Full Paper Access

32

Citations

31

References

2022

Year

Mengdi Yang, Dan Li, Zhiyuan Jiang, Changcan Li, Suyuan Ji, Jing Ping Sun, Yujie Chang, Shunyi Ruan, Zhiyu Wang, Rui Liang,

Molecular Cancer Research

Abstract

CAFs enhance colorectal cancer aggressiveness by reducing FLRT3 expression through activating TGF-β/SMAD4 signaling pathway. CAF-targeted therapy and/or LY2109761 were promising treatments for colorectal cancer.

References

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