IgA AND RING-18 CHROMOSOME

A familial disorder of uric acid metabolism and central nervous system function

Michael Lesch, William L. Nyhan · The American Journal of Medicine · 1964 · 1.5K citations

Life Sciences, Neurology, Neuroscience +9

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

J. Edwin Seegmiller, Frederick M. Rosenbloom, William N. Kelley · Science · 1967 · 1.2K citations

Life Sciences, Biochemistry, Neurology +14

Genetics of an X-Linked Disorder of Uric Acid Metabolism and Cerebral Function

William L. Nyhan, Joseph J. Pesek, Lawrence Sweetman et al. · Pediatric Research · 1967 · 111 citations

Life Sciences, Genetics, Neuroscience +12

An Enzymatic Basis for Variation in Response to Allopurinol

William N. Kelley, Frederick M. Rosenbloom, J. Philip Miller et al. · New England Journal of Medicine · 1968 · 93 citations

Life Sciences, Biochemistry, Pharmacology +12

The Effects of Azathioprine (Imuran) on Purine Synthesis in Clinical Disorders of Purine Metabolism*

William N. Kelley, Frederick M. Rosenbloom, J. Edwin Seegmiller · Journal of Clinical Investigation · 1967 · 86 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14