Hydrolethalus syndrome.

Abstract

Hydrolethalus syndrome is a lethal malformation syndrome with hydrocephalus, micrognathia, and polydactyly as the most obvious symptoms. Many of the patients are stillborn and the survival of the others has not been long. Hydrolethalus syndrome was recognised as a consequence of a study on Meckel syndrome in Finland.' Apart from the first 28 cases, there are another 28 Finnish cases that we know about. This means an incidence of at least 1:20 000 in Finland. A few reports of the syndrome have been published from elsewhere.26