A Controlled Evaluation of Lithium in the Premenstrual Tension Syndrome

Abstract

Good results with the use of lithium salts in the premenstrual tension syndrome have been reported (Sletten and Gershon, 1966); these observations await confirmation. The value of lithium is suggested by its known capacity to affect water and electrolyte balance implicated in the pathophysiology of the syndrome, and by its efficacy in psychiatric disorders characterized by periodicity. We therefore undertook a controlled study on the efficacy of lithium in the syndrome.