Anti-Tuberculosis Coumarinolignans from Daphne mucronata

Abstract

Two new linearly fused coumarinolignans named mucronin-A (1) and mucronin-B (2) have been isolated from the whole plant of Daphne mucronata along with two other known compounds i.e., umbelliferone (3) and coumarin (4).The structures of the isolated compounds 1-4 were elucidated by chemical and spectroscopic methods including 1D-NMR, 2D-NMR and HR-FAB-MS.Both of the new isolated compounds 1 and 2 showed significant antituberculosis activity.