T-cell receptor gene rearrangement in regressing atypical histiocytosis

Abstract

† A case of regressing atypical histiocytosis having characteristic clinical and light microscopic findings was studied immunologically for immunoglobulin and T-cell receptor gene rearrangement and for DNA ploidy analysis. Immunologic phenotyping and rearrangement of T-cell receptor β- and γ-chain genes indicated that this primary cutaneous neoplasm, previously considered "histiocytic" in origin, is most probably of T-cell lineage. (<i>Arch Dermatol</i>1987;123:1183-1187)