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Flow cytometry based enumeration and functional characterization of CD8 T regulatory cells in patients with multiple myeloma before and after lenalidomide plus dexamethasone treatment
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2013
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ImmunologyPathologyPlasma CellsImmunotherapyMyeloid NeoplasiaHematological MalignancyHematologyCell TransplantationDexamethasone TreatmentFlow CytometryAutoimmune DiseaseAutoimmunityCell BiologyTumor MicroenvironmentMalignant Blood DisorderMultiple MyelomaAdult T-cell Leukemia-lymphomaMedicineMm Immune Deregulation
Multiple myeloma (MM) is a malignancy of plasma cells frequently associated with immune abnormalities. Several studies have confirmed that in MM immune deregulation can be mediated by increased numbers of CD4 T regulatory (Treg) cells, and these cells were also associated with poor outcome. In the present study, we aimed to study CD8 Treg cells before and after lenalidomide plus dexamethasone (len-dex) treatment in MM patients.