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2,3,7,8-Tetrachlorodibenzo-p-dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report
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1986
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Metabolic DisorderOccupational Health SciencesExposure AssessmentOccupational ExposureOxidative StressMetabolic SyndromeBody CompositionEnvironmental HealthToxicologyClinical ChemistryPublic HealthHuman MetabolismHuman BiomonitoringClinical ToxicologyControl Group2,3,7,8-Tetrachlorodibenzo-p-dioxin LevelsAdipose TissueHuman ExposurePharmacologyMetabolic HealthOccupational ToxicologyPhysiologyForensic ToxicologyControl PersonsEnvironmental DiseaseEnvironmental ToxicologyMetabolismMedicine
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin, commonly known as dioxin, was measured in the adipose tissue of 39 persons with a history of residential, recreational, or occupational exposure in Missouri and in 57 persons in a control group. All participants had detectable levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in their adipose tissue, but the exposed group had significantly higher levels. Levels of six of the exposed persons were more than five times greater than the level of the highest control. Measuring 2,3,7,8-tetrachlorodibenzo-p-dioxin in adipose tissue provides a much improved index of exposure, an important advance for research studies evaluating the possible health effects of this compound. (<i>JAMA</i>1986;256:2683-2686)