Modeling of the 5′‐Deiodination of Thyroxine by Iodothyronine Deiodinase: Chemical Corroboration of a Selenenyl Iodide Intermediate

Abstract

Was macht eine gute Höhle aus? Ein molekularer Hohlraum ermöglichte die Stabilisierung eines Selenenyliodid(RSeI)-Intermediats, das bei der Abspaltung des 5′-Iodsubstituenten eines Thyroxinderivats mit einem Organoselenol entsteht (siehe Schema). Die für den Iodthyronin-Deiodinase-Katalysezyklus vorgeschlagenen chemischen Prozesse wurden experimentell bestätigt. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.