Concepedia

Synthesis of Potential Cytotoxic α-Methylene γ-Lactams

C. BELAUD, Christos Roussakis, Yves Letourneux, Najat El Alami, J. Villiéras

Synthetic Communications · 1985 · 84 citations · 5 references

DOI

Concepts

Abstract

Abstract α-Methylene γ-lactones are known to have physiological activity, especially as cytotoxic agents, and are widely found in nature (1). However they are often toxic which makes them inappropriate for cancer treatment.

References

5

Methods for the Synthesis of α-Methylene Lactones

Paul A. Grieco · Synthesis · 1975 · 254 citations

, , +6

Wittig-Horner Reaction in Heterogeneous Media; 1. An Easy Synthesis of Ethyl α-Hydroxymethylacrylate and Ethyl α-Halomethylacrylates using Formaldehyde in Water

J. Villiéras, M. Rambaud · Synthesis · 2002 · 218 citations

, , +3

Tumor inhibitors. LXXXX. Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea

S. Morris Kupchan, Ronald W. Britton, Myra F. Ziegler et al. · Journal of the American Chemical Society · 1973 · 212 citations

, , +6

Interaction of some colchicine analogs, vinblastine and podophyllotoxin with rat brain microtubule protein

M H Zweig, Colin F. Chignell · Biochemical Pharmacology · 1973 · 100 citations

, , +12

Novel Synthesis of α-Methylene-β-lactams

Toshio Agawa, Masaru Ishida, Yoshiki Ohshiro · Synthesis · 1980 · 20 citations

, , +10