MedicineInfectious DiseasesNephrologyPediatric NephrologyRenal PathologyRenal PathophysiologyChronic Kidney DiseaseGlomerular DiseasesInterstitial NephritisRenal DiseaseRenal ImmunopathologyRenal InflammationBacterial Renal DiseaseBrucella SpeciesChronic Interstitial NephritisInfectious Interstitial NephritisInfectious NephritisRenal Pathogenesis
Two patients with Brucella suis infection had severe renal involvement. Clinical features included transient azotemia, massive proteinuria, hypertension, and later frequency and dysuria. Renal morphological studies revealed a diffuse interstitial nephritis with focal and local glomerular lesions. In one patient clinical and pathological signs of renal disease persisted for over 3 years, suggesting that brucellosis may be a precursor of chronic renal disease.
7