Salicylate induces an antibiotic efflux pump in Burkholderia cepacia complex genomovar III (B. cenocepacia)

Abstract

individuals with CF. Intrinsic resistance to the aminoglycosides is related to lack of binding to lipopolysaccharide in the outer membrane Resistance to the -lactam antibiotics appears to be caused by synergistic mechanisms, including the induction of chromosomal -lactamases (12, 13) and decreased drug access Other mechanisms of resistance may also be related to diminished antibiotic access (16), including drug efflux (17).