Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes

Abstract

Der Cinchona-Sulfonamid-Organokatalysator 1 vermittelt die hoch enantioselektive biomimetische Aldolreaktion von Malonsäure-Halbthioestern mit vielfältigen Aldehyden unter Bildung von optisch aktiven β-Hydroxythioestern. Das Verfahren bewährte sich in Formalsynthesen der Antidepressiva (R)-Fluoxetin, (R)-Tomoxetin, (−)-Paroxetin und (R)-Duloxetin. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.