Adapters in lymphocyte signaling

Abstract

Adapters in signaling through the TCR Among the best-characterized membrane-associated signaling scaffolds in T cells is the Ca 2+ -initiation complex, which comprises LAT (a TRAP), Gads and SLP-76 (both CAPs), the effector molecules PLCγ1 and Itk (a PTK of the Tec family), and the Grb2/SOS complex, which activates p21 ras (2).The current model for Ca 2+ -