Cephalosporin‐3′‐diazeniumdiolates: Targeted NO‐Donor Prodrugs for Dispersing Bacterial Biofilms

Abstract

Kampf gegen Biofilme: Mit NO-Donoren lässt sich ein bakterieller Biofilm dispergieren, und damit können mitverabreichte Antibiotika die empfindlicheren freien Zellen töten. Das chemisch stabile Cephalosporin-3′-diazeniumdiolat-NO-Donor-Pharmakon (siehe Schema) wird durch bakterielle β-Lactamasen aktiviert und erleichtert diese zweistufige Biofilmentfernung. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.