Inhibition of Beta‐Amyloid Peptide Aggregation by Multifunctional Carbazole‐Based Fluorophores

Abstract

Aggregation ausgeschlossen: Carbazol-basierte Cyaninfluorophore binden selektiv an das Aβ(1–40)-Peptid und dessen Aggregate, die zur Entstehung der Alzheimer-Krankheit führen. Ein solcher Fluorophor, SLOH, hemmt wirksam die Bildung von Aβ(1–40)-Fibrillen (siehe Schema); da er die Blut-Hirn-Schranke passieren kann, ist er ein potenzielles Alzheimer-Therapeutikum. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.