Enantioselective Reaction of 2<i>H</i>‐Azirines with Phosphite Using Chiral Bis(imidazoline)/Zinc(II) Catalysts

Abstract

Abstract The first highly enantioselective nucleophilic addition reaction of phosphites with 2 H ‐azirines has been developed. The reaction was applied to various 3‐substituted 2 H ‐azirines using novel chiral bis(imidazoline)/Zn II catalysts to afford products in good yield with high enantioselectivity. The transformation of the obtained optically active aziridines showed that 2 H ‐azirines act as either α,β‐ or β,β‐dicarbocationic amine synthons.