Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

Abstract

Nonstandard abbreviations used: glucose-stimulated insulin secretion (GSIS); uncoupling protein (UCP); reactive oxygen species (ROS); triphenylmethylphosphonium cation (TPMP + ); 3 H-labeled triphenylmethylphosphonium ([ 3 H]TPMP + ); Mn(III)tetrakis(4-benzoic acid)porphyrin (MnTBAP); tetramethyl rhodamine methyl ester (TMRM)